PXD021229

PXD021229 is an original dataset announced via ProteomeXchange.

Title	Fasnall induces atpically transient Stress Granules
Description	Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granules formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of non-canonical Stress Granules with a faster clearing and internal dynamics kinetics independently of fatty acid synthase inhibition. PABPC1 BioID interactomes in fasnall, and arsenite conditions were obtained.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_09:09:13.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Triana Amen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-31 22:21:55	ID requested
⏵ 1	2021-09-09 09:09:13	announced

Amen T, Kaganovich D, Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition. iScience, 23(10):101550(2020) [pubmed]

submitter keyword: fasnall, PABPC1, stress granule

Daniel Kaganovich
contact affiliation	Department of Experimental Neurodegeneration, University Medical Center Goettingen
contact email	danielkaganovich@gmail.com
lab head
Triana Amen
contact affiliation	University Medical Center Goettingen
contact email	amentri@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021229
     1. Label: PRIDE project
     2. Name: Fasnall induces atpically transient Stress Granules