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PXD021211

PXD021211 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStructure of TFIIK for phosphorylation of CTD of RNA polymerase II
DescriptionTFIIH is a 10-protein complex that is conserved through out eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). In transcription initiation, TFIIH acts as a structural scaffold, phosphorylates the RNA polymerase II (pol II) C-terminal domain (CTD) and translocates promoter DNA through the pol II active site to facilitate start site selection. In NER, again is a structural scaffold, opens a bubble around damaged DNA and scans the damaged strand for bulky lesions. In yeast (Saccharomyces cerevisiae), TFIIH is composed of the two helicases Ssl2 and Rad3, the scaffolding subunits Tfb1, Tfb2, Tfb4 and Ssl1 and the kinase subunits Kin28, Ccl1 and Tfb3.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:23:46.249.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHee Jong Kim
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-08-31 01:28:32ID requested
12021-07-06 22:35:59announced
22024-10-22 05:23:47announced2024-10-22: Updated project metadata.
Publication List
van Eeuwen T, Li T, Kim HJ, Gorbea Col, รณ, n JJ, Parker MI, Dunbrack RL, Garcia BA, Tsai KL, Murakami K, Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. Sci Adv, 7(15):(2021) [pubmed]
10.1126/sciadv.abd4420;
Keyword List
submitter keyword: transcription,TFIIK, phosphorylation
Contact List
Benjamin Aaron Garcia
contact affiliationUniversity of Pennsylvania
contact emailbgarci@pennmedicine.upenn.edu
lab head
Hee Jong Kim
contact affiliationUniversity of Pennsylvania
contact emailheejong@heejong.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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