PXD021211 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Structure of TFIIK for phosphorylation of CTD of RNA polymerase II |
Description | TFIIH is a 10-protein complex that is conserved through out eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). In transcription initiation, TFIIH acts as a structural scaffold, phosphorylates the RNA polymerase II (pol II) C-terminal domain (CTD) and translocates promoter DNA through the pol II active site to facilitate start site selection. In NER, again is a structural scaffold, opens a bubble around damaged DNA and scans the damaged strand for bulky lesions. In yeast (Saccharomyces cerevisiae), TFIIH is composed of the two helicases Ssl2 and Rad3, the scaffolding subunits Tfb1, Tfb2, Tfb4 and Ssl1 and the kinase subunits Kin28, Ccl1 and Tfb3. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:23:46.249.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hee Jong Kim |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-31 01:28:32 | ID requested | |
1 | 2021-07-06 22:35:59 | announced | |
⏵ 2 | 2024-10-22 05:23:47 | announced | 2024-10-22: Updated project metadata. |
Publication List
van Eeuwen T, Li T, Kim HJ, Gorbea Col, รณ, n JJ, Parker MI, Dunbrack RL, Garcia BA, Tsai KL, Murakami K, Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. Sci Adv, 7(15):(2021) [pubmed] |
10.1126/sciadv.abd4420; |
Keyword List
submitter keyword: transcription,TFIIK, phosphorylation |
Contact List
Benjamin Aaron Garcia |
contact affiliation | University of Pennsylvania |
contact email | bgarci@pennmedicine.upenn.edu |
lab head | |
Hee Jong Kim |
contact affiliation | University of Pennsylvania |
contact email | heejong@heejong.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD021211 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021211
- Label: PRIDE project
- Name: Structure of TFIIK for phosphorylation of CTD of RNA polymerase II