PXD021181 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast CancerA Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast Cancer |
Description | Breast cancer is one of the most common types of cancer in women. One key signaling pathway known to regulate tumor growth, metabolic adaptation, and cellular stress response in breast cancer is Wnt signaling. Breast cancer patients, specifically triple negative breast cancer (TNBC), with upregulated Wnt signaling often have a poor clinical prognosis. However, the effects of Wnt/β-catenin signaling on the nucleolus and the resultant impact on cancer development and progression remain unclear. A notable reduction was observed in the number of nucleoli per nucleus in response to Wnt/β-catenin signaling inhibition in multiple TNBC cell lines. Our comparative proteomic analysis revealed several changes in the composition of the nucleolar proteome of TNBC cells upon inhibition of Wnt signaling. Overall, we demonstrate that Wnt/β-catenin signaling will affects nucleolar functionality and thus influences breast cancer progression. Understanding the role of Wnt signaling in the nucleolus and breast cancer is a critical step towards developing novel therapeutic options for the treatment of breast cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-05 |
AnnouncementXML | Submission_2021-03-04_22:38:11.328.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD021181 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Brandon Metge |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-28 00:08:19 | ID requested | |
⏵ 1 | 2021-03-04 22:38:11 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Wnt signaling, Beta Catenin, Triple negative breast cancer, Nucleolus, Nucleolar Proteome, LAS1L |
Contact List
Rajeev Samant |
contact affiliation | University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center |
contact email | rajeevsamant@uabmc.edu |
lab head | |
Brandon Metge |
contact affiliation | University of Alabama at Birmingham |
contact email | brandonmetge@uabmc.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021181
- Label: PRIDE project
- Name: A Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast CancerA Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast Cancer