PXD021178

PXD021178 is an original dataset announced via ProteomeXchange.

Title	Proteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls
Description	Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by hyper-proliferation of the erythroid, megakaryocytic and granulocytic lineages and the presence of an activating mutation in JAK2. To elucidate mechanisms that regulate PV stem cells, we applied a newly developed data-independent acquisition (DIA) mass spectrometry (MS) technology to purified hematopoietic stem and progenitor cell (HSPC) subpopulations of patients with chronic and progressed PV. Proteomic analyses were supplemented by RNA-sequencing (RNA-seq) and identified targets validated by flow cytometry and functional in vitro assays.
HostingRepository	PRIDE
AnnounceDate	2022-01-19
AnnouncementXML	Submission_2022-01-19_09:02:28.797.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabienne Meier-Abt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-27 23:32:43	ID requested
⏵ 1	2022-01-19 09:02:29	announced

Dataset with its publication pending

submitter keyword: Human, hematopoietic stem and progenitor cell subpopulations, polycythemia vera

Fabienne Meier-Abt
contact affiliation	Department of Medical Oncology and Hematology, University and University Hospital Zurich, Zurich, Switzerland Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
contact email	fabienne.meier-abt@usz.ch
lab head
Fabienne Meier-Abt
contact affiliation	University Hospital Zurich ETHZ
contact email	fabienne.meier-abt@usz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD021178

PRIDE project URI

• PRIDE
  1. PXD021178
     1. Label: PRIDE project
     2. Name: Proteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls