PXD021147
PXD021147 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease |
| Description | Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quantify differences between visceral adipose tissue samples from obese women with and without DM. Results: 2640 protein groups were identified and 1965 were subject to statistical analysis. 23 were differently abundant between groups (q < 0.1, moderated t-test, n = 10). Proteins localized to the mitochondria or involved in mitochondrial functions including the TCA cycle and fatty acid metabolism were decreased in abundance in samples from women with DM relative to NDM samples while proteins involved in cytoskeletal function and innate inflammatory signaling pathways were increased. Conclusion: The visceral adipose tissue proteome in DM is characterized by defects in mitochondrial function, TCA metabolism, inflammation and immunity, and cytoskeletal function. Alterations in the levels of specific proteins associated with these pathways provide insight into mechanisms of adipose tissue dysfunction in the context of metabolic disease. |
| HostingRepository | MassIVE |
| AnnounceDate | 2021-12-22 |
| AnnouncementXML | Submission_2021-12-22_07:50:18.531.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nick Carruthers |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; L-methionine (R)-sulfoxide |
| Instrument | Orbitrap Fusion ETD |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-08-26 13:17:15 | ID requested | |
| ⏵ 1 | 2021-12-22 07:50:19 | announced |
Publication List
| Carruthers NJ, Strieder-Barboza C, Caruso JA, Flesher CG, Baker NA, Kerk SA, Ky A, Ehlers AP, Varban OA, Lyssiotis CA, Lumeng CN, Stemmer PM, O'Rourke RW, The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity. Sci Rep, 11(1):17394(2021) [pubmed] |
Keyword List
| submitter keyword: adipose tissue, diabetes, mitochondria, obesity, proteome, proteomics, visceral |
Contact List
| Robert W. O'Rourke | |
|---|---|
| contact affiliation | University of Michigan |
| contact email | rorourke@med.umich.edu |
| lab head | |
| Nick Carruthers | |
| contact affiliation | Wayne State U |
| contact email | carruthers@wayne.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085169/ |
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