PXD021100

PXD021100 is an original dataset announced via ProteomeXchange.

Title	Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Description	In order to further understand how glioma-derived IL-33 is orchestrating changes within the tumor microenvironment and based on the significant increase of anti-inflammatory mediators including a number of signaling molecules observed in IL-33+ tumors, we performed phospho-proteomic analysis using mass spectrometry on the brains of tumor-bearing mice.
HostingRepository	PRIDE
AnnounceDate	2020-08-28
AnnouncementXML	Submission_2020-10-19_00:53:44.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021100
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Shyam Menon
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-25 01:02:50	ID requested
1	2020-08-27 23:04:06	announced
⏵ 2	2020-10-19 00:53:45	announced	2020-10-19: Updated publication reference for PubMed record(s): 33020472.

De Boeck A, Ahn BY, D'Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL, Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression. Nat Commun, 11(1):4997(2020) [pubmed]

submitter keyword: IL-33, Tumor Microenvironment (TME), Tumor associated macrophages/monocytes/microglia, Glioma, Human Glioblastoma (GBM), Phosphoproteomics

Stephen Mark Robbins
contact affiliation	Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
contact email	srobbins@ucalgary.ca
lab head
Shyam Menon
contact affiliation	University of Calgary
contact email	shyam.menon@ucalgary.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD021100

PRIDE project URI

• PRIDE
  1. PXD021100
     1. Label: PRIDE project
     2. Name: Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression