PXD021077

PXD021077 is an original dataset announced via ProteomeXchange.

Title	A proteomics-based assessment of inflammation signatures in endotoxemia
Description	The circulating proteome offers insight into the stage and severity of the immune response. To characterise the release kinetics and cellular source of plasma protein changes, serial samples were obtained from healthy volunteers (n=10, 3 time-points) injected with low-dose endotoxin (LPS) and analysed using date-independent acquisition (DIA) MS. The systemic and vascular inflammatory responses were compared using LPS-induced endotoxemia models in mice.
HostingRepository	PRIDE
AnnounceDate	2021-02-12
AnnouncementXML	Submission_2021-02-11_22:24:05.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sean Burnap
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-24 03:19:40	ID requested
1	2021-02-11 11:51:25	announced
⏵ 2	2021-02-11 22:24:06	announced	2021-02-12: Updated project metadata.

10.1074/MCP.RA120.002305;

Burnap SA, Mayr U, Shankar-Hari M, Cuello F, Thomas MR, Shah AM, Sabroe I, Storey RF, Mayr M, A Proteomics-Based Assessment of Inflammation Signatures in Endotoxemia. Mol Cell Proteomics, 20():100021(2021) [pubmed]

submitter keyword: Human, Mouse, DIA, Endotoxemia, LPS, TMT, Plasma, Aorta

Manuel Mayr
contact affiliation	King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, UK
contact email	manuel.mayr@kcl.ac.uk
lab head
Sean Burnap
contact affiliation	King's College London
contact email	sean.a.burnap@kcl.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD021077

PRIDE project URI

• PRIDE
  1. PXD021077
     1. Label: PRIDE project
     2. Name: A proteomics-based assessment of inflammation signatures in endotoxemia