PXD021056

PXD021056 is an original dataset announced via ProteomeXchange.

Title	Mouse cerebellum LC-MSMS: effect of calorie restriction
Description	The cerebellum harbors a circadian clock that can be shifted by scheduled mealtime and participates in behavioral anticipation of food access. To determine which cerebellar proteins are modified by time-of-day and/or feeding time, we determined day-night variations of proteome in the cerebellum of mice fed either ad libitum or only during daytime (from noon to lights off). Two-dimensional differences in gel electrophoresis (2D-DIGE) combined with two-way analyses of variance reveals that a majority of cerebellar proteins are significantly regulated by feeding conditions (food availability). Levels of few other cerebellar proteins were modulated exclusively by daily (or circadian) cues, independent of meal time, and others due to combined influence of meal time and time-of-day. Changes reflect behavioral anticipation of mealtime and/or feeding-induced shift in the circadian clock of the cerebellum.
HostingRepository	PRIDE
AnnounceDate	2021-04-06
AnnouncementXML	Submission_2021-05-03_21:48:30.101.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabrice BERTILE
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	maXis 4G; Synapt HDMS

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-22 16:12:19	ID requested
1	2021-04-06 06:42:00	announced
⏵ 2	2021-05-03 21:48:31	announced	2021-05-04: Updated publication reference for PubMed record(s): 33912010.

Bertile F, Plumel M, Maes P, Hirschler A, Challet E, Daytime Restricted Feeding Affects Day-Night Variations in Mouse Cerebellar Proteome. Front Mol Neurosci, 14():613161(2021) [pubmed]

submitter keyword: Mouse, cerebellum, circadian rhythm, LC-MSMS

Sarah Cianférani
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, france
contact email	sarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliation	CNRS
contact email	fbertile@unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD021056

PRIDE project URI

• PRIDE
  1. PXD021056
     1. Label: PRIDE project
     2. Name: Mouse cerebellum LC-MSMS: effect of calorie restriction