PXD021046

PXD021046 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of insulin sensitive tissues in high fat diet fed mice
Description	The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To uncover the mechanism by which excessive fat impairs insulin sensitivity, we conducted a multi- tissue study by using TMT-based quantitative proteomics. 3-week-old ICR mice were fed with high fat diet (HFD) for 19 weeks to induce insulin resistance. Liver, skeletal muscle and epididymal fat were collected for proteomics screening. Additionally, PRM was used for validating adipose differential proteins. By comparing tissue-specific protein profiles of HFD mice, multi-tissue regulation of glucose and lipid homeostasis and corresponding underlying mechanisms was systematically investigated and characterized. NC: normal birth weight + chow diet; NH: normal birth weight + high fat diet; LC: low birth weight + chow diet; LH: low birth weight + high fat diet.
HostingRepository	PRIDE
AnnounceDate	2022-01-26
AnnouncementXML	Submission_2022-01-26_02:35:09.910.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linlin Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-21 03:30:40	ID requested
⏵ 1	2022-01-26 02:35:10	announced

Dataset with its publication pending

submitter keyword: insulin resistance

high fat diet

multi-tissue analysis

Huijuan Ma
contact affiliation	Hebei Key Laboratory of Metabolic Diseases
contact email	huijuanma76@163.com
lab head
Linlin Yang
contact affiliation	Hebei Key Laboratory of Metabolic Diseases
contact email	ll.yang@foxmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021046
     1. Label: PRIDE project
     2. Name: Proteomics analysis of insulin sensitive tissues in high fat diet fed mice