PXD021031

PXD021031 is an original dataset announced via ProteomeXchange.

Title	Identification of signalling pathways downstream of ARHGEF17
Description	Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression albeit with often uncharacterized roles in altering cell signaling states. We developed a computational approach to predict regulators of signaling from the integrative analysis of genomic and proteomic pan-cancer datasets. Among the predictions, we identified ARHGEF17 to be a regulator of hippo-signaling and performed (phospho)proteomics analysis to test these predictions.
HostingRepository	PRIDE
AnnounceDate	2021-04-06
AnnouncementXML	Submission_2021-04-05_23:29:37.940.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Danish Memon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-20 22:34:24	ID requested
⏵ 1	2021-04-05 23:29:38	announced

Dataset with its publication pending

submitter keyword: TEM4

Pedro Beltrao
contact affiliation	European Bioinformatics Institute (EMBL-EBI), UK
contact email	pbeltrao@ebi.ac.uk
lab head
Danish Memon
contact affiliation	European Bioinformatics Institute
contact email	memon@ebi.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021031
     1. Label: PRIDE project
     2. Name: Identification of signalling pathways downstream of ARHGEF17