PXD021019

PXD021019 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomics analysis of white adipose tissue in high fat diet fed mice
Description	The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To uncover the mechanism by which excessive fat impairs insulin sensitivity, we conducted a multi- tissue study by using TMT-based quantitative proteomics. 3-week-old ICR mice were fed with high fat diet (HFD) for 19 weeks to induce insulin resistance. Liver, skeletal muscle and epididymal fat were collected for proteomics screening. Additionally, PRM was used for validating adipose differential proteins. By comparing tissue-specific protein profiles of HFD mice, multi-tissue regulation of glucose and lipid homeostasis and corresponding underlying mechanisms was systematically investigated and characterized.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:36:51.089.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linlin Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-20 03:47:13	ID requested
1	2022-05-25 05:09:20	announced
⏵ 2	2024-10-22 05:36:51	announced	2024-10-22: Updated project metadata.

Publication List

10.2147/dmso.s353095;
Wang J, Yang L, Yang L, Zhou F, Zhao H, Liu J, Ma H, Song G, Adipose Dysfunction in Adulthood Insulin Resistance of Low-Birth Weight Mice: A Proteomics Study. Diabetes Metab Syndr Obes, 15():849-862(2022) [pubmed]

10.2147/dmso.s353095;

Wang J, Yang L, Yang L, Zhou F, Zhao H, Liu J, Ma H, Song G, Adipose Dysfunction in Adulthood Insulin Resistance of Low-Birth Weight Mice: A Proteomics Study. Diabetes Metab Syndr Obes, 15():849-862(2022) [pubmed]

Keyword List

submitter keyword: insulin resistance
high fat diet
multi-tissue analysis

submitter keyword: insulin resistance

high fat diet

multi-tissue analysis

Contact List

Huijuan Ma
contact affiliation	Hebei Key Laboratory of Metabolic Diseases
contact email	huijuanma76@163.com
lab head
Linlin Yang
contact affiliation	Hebei Key Laboratory of Metabolic Diseases
contact email	ll.yang@foxmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD021019
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD021019

PRIDE project URI

Repository Record List

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