PXD020987

PXD020987 is an original dataset announced via ProteomeXchange.

Title	Quantitative LC-MS/MS Proteomics of human small intestine
Description	The objective was to determine the expression of a wide range proteins pertinent to metabolism and disposition of chemicals and nutrients in the intestinal epithelium. Ileum and jejunum biopsy specimens were obtained from 16 patients undergoing gastrointestinal elective surgery. Mucosal fractions were prepared and analysed using targeted and global proteomic approaches. A total of 29 enzymes, 32 transporters, 6 tight junction proteins, 2 adhesion proteins, alkaline phosphatase, thioredoxin, 5 markers and 1 regulatory protein were quantified; 60 for the first time.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_07:10:34.870.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jill Barber
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-18 22:58:00	ID requested
⏵ 1	2021-09-09 07:10:35	announced

Al-Majdoub ZM, Achour B, Couto N, Howard M, Elmorsi Y, Scotcher D, Alrubia S, El-Khateeb E, Vasilogianni AM, Alohali N, Neuhoff S, Schmitt L, Rostami-Hodjegan A, Barber J, Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin. FEBS Lett, 594(23):4134-4150(2020) [pubmed]

submitter keyword: Human, jejunum, ileum, small intestine, gut, LC-MS/MS, quantitative proteomics

Jill Barber
contact affiliation	Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, UK
contact email	jill.barber@manchester.ac.uk
lab head
Jill Barber
contact affiliation	The University of Manchester
contact email	Jill.barber@manchester.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD020987

PRIDE project URI

• PRIDE
  1. PXD020987
     1. Label: PRIDE project
     2. Name: Quantitative LC-MS/MS Proteomics of human small intestine