PXD020975

PXD020975 is an original dataset announced via ProteomeXchange.

Title	Small extracellular vesicles in human uterine fluid
Description	Extracellular vesicles (EVs) released by endometrium into the uterine fluid are emerging as an important mediator of intercellular communication between mother and the embryo. Here, we show that these EVs are dynamically regulated for their protein composition during the natural menstrual cycle, and transfer invasive properties and antioxidant function to trophectoderm cells. These EVs carry proteins that regulate embryo implantation and predict window of implantation, thus highlighting their potential as a minimally invasive biomarker. Clinical applications could include use of nanoparticles engineered to contain the most relevant proteins and delivered at the time of embryo transfer, to improve implantation success. Alternatively, it could be applied to the development of a new class of non-steroidal once-a month contraceptive.
HostingRepository	PRIDE
AnnounceDate	2021-03-18
AnnouncementXML	Submission_2021-03-18_00:36:19.074.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Dreening
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-18 05:24:55	ID requested
⏵ 1	2021-03-18 00:36:19	announced

Dataset with its publication pending

submitter keyword: extracellular vesicles, uterine fluid, embryo implantation, fertility, proteomics

David Greening
contact affiliation	Baker Institute
contact email	david.greening@baker.edu.au
lab head
David Dreening
contact affiliation	Baker Heart and Diabetes Inst.
contact email	david.greening@baker.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD020975

PRIDE project URI

• PRIDE
  1. PXD020975
     1. Label: PRIDE project
     2. Name: Small extracellular vesicles in human uterine fluid