PXD020972

PXD020972 is an original dataset announced via ProteomeXchange.

Title	Proteomics of induced senescent cells
Description	OMI (Uniprot ID O43464) is a pro-apoptotic protease localized to the mitochondria which was hypothesized to activate senescense following X-ray irradiation via cleavage of specific ligands. To elucidate cellular processes affected by OMI after irradiation, human lung cancer cell line was subjected to the following treatments: WT + X-ray irradiation WT - X-ray irradiation WT + OMI-inhibitor + X-ray irradiation WT + OMI-inhibitor - X-ray irradiation OMI-siRNA + X-ray irradiation OMI-siRNA - X-ray irradiation siRNA-empty vector (control) + X-ray irradiation siRNA-empty vector (control) - X-ray irradiation
HostingRepository	PRIDE
AnnounceDate	2022-01-30
AnnouncementXML	Submission_2022-01-30_13:43:36.009.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alon Savidor
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-18 04:52:29	ID requested
⏵ 1	2022-01-30 13:43:36	announced

Dataset with its publication pending

submitter keyword: Human, senescence, LC-MS/MS, x-ray irradiation, OMI

Prof. Adi Kimchi
contact affiliation	Department of Molecular Genetics Faculty of Biochemistry Weizmann Institute of Science, Rehovot, Israel
contact email	adi.kimchi@weizmann.ac.il
lab head
Alon Savidor
contact affiliation	The Weizmann Institute of Science
contact email	alon.savidor@weizmann.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD020972

PRIDE project URI

• PRIDE
  1. PXD020972
     1. Label: PRIDE project
     2. Name: Proteomics of induced senescent cells