PXD020948

PXD020948 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comprehensive Proteomic Analysis of Exosomes Derived from Human Bone Marrow-, Adipose Tissue-, and Human Umbilical Cord- Mesenchymal Stem Cells
Description	Mesenchymal stem cells (MSCs)-derived exosomes (exo) have shown comprehensive application prospects over the years. Despite similar functions, exomes from different origins present heterogeneous characteristics and components; however, there are no relevant proteomic analyses. In this study, we isolated exosomes from MSCs, derived from different tissues, by ultracentrifugation. A total of 1014 proteins were detected using a label-free method and analyzed with bioinformatics tools. The results revealed their shared function in the extracellular matrix receptor. Bone marrow-MSCs-derived exosomes showed superior regeneration ability. Likewise, adipose tissue-MSCs-derived exosomes played a significant role in immune regulation. Whereas, umbilical cord-MSCs-derived exosomes were more prominent in tissue damage repair.
HostingRepository	PRIDE
AnnounceDate	2021-04-15
AnnouncementXML	Submission_2021-04-14_21:13:15.192.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhenggang Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-17 03:24:18	ID requested
1	2021-04-14 06:52:57	announced
⏵ 2	2021-04-14 21:13:16	announced	2021-04-15: Updated project metadata.

Publication List

10.1186/S13287-020-02032-8;
Wang ZG, He ZY, Liang S, Yang Q, Cheng P, Chen AM, Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells. Stem Cell Res Ther, 11(1):511(2020) [pubmed]

10.1186/S13287-020-02032-8;

Wang ZG, He ZY, Liang S, Yang Q, Cheng P, Chen AM, Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells. Stem Cell Res Ther, 11(1):511(2020) [pubmed]

Keyword List

submitter keyword: Mesenchymal stem cells
Exosomes
Proteomics
Extracellular vesicles
Stem cell-based therapy.

submitter keyword: Mesenchymal stem cells

Exosomes

Proteomics

Extracellular vesicles

Stem cell-based therapy.

Contact List

Zheng-gang Wang
contact affiliation	Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China
contact email	846735564@qq.com
lab head
Zhenggang Wang
contact affiliation	Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
contact email	846735564@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD020948
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD020948

PRIDE project URI

Repository Record List

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