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PXD020900

PXD020900 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStreamlining of defenses against copper makes host-restricted pathogen reliant on custom-made operon
DescriptionCopper is both essential and toxic to living beings, which therefore tightly control its intracellular concentration. At the host-pathogen interface, copper is used by phagocytic cells to kill invading microorganisms. We investigated copper homeostasis in the whooping cough agent Bordetella pertussis, which lives in the human respiratory mucosa and has no environmental reservoir. B. pertussis has considerably streamlined copper homeostasis mechanisms relative to other Gram-negative bacteria. Its single remaining defense line against copper intoxication consists in a metallochaperone diverted for copper passivation and two enzymes involved in peroxide detoxification, which together fight two stresses encountered in phagolysosomes. The three proteins are encoded by an original, composite operon assembled in an environmental ancestor and which is under sensitive control by copper. Interestingly, this system appears to play a role in persistent infection in the nasal cavity of B. pertussis-infected mice. Combining responses to co-occurring stresses in a tailored operon reveals a new strategy adopted by a host-restricted pathogen to optimize survival at minimal energy expenditure.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_04:23:52.539.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD020900
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterSALIOU Jean-Michel
SpeciesList scientific name: Bordetella bronchiseptica; NCBI TaxID: 518;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-08-13 22:40:31ID requested
12021-09-09 04:23:53announced
Publication List
Rivera-Millot A, Slupek S, Chatagnon J, Roy G, Saliou JM, Billon G, Alaimo V, Hot D, Salom, é, -Desnoulez S, Locht C, Antoine R, Jacob-Dubuisson F, Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon. Commun Biol, 4(1):46(2021) [pubmed]
Keyword List
submitter keyword: Bordetella pertussis, Copper homeostasis, Phagocytosis, oxidative stress, Evolution, Metallochaperone, host-restricted pathogen
Contact List
Saliou Jean-Michel
contact affiliationUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41 – UMS 2014 – PLBS, F-59000 Lille, France
contact emailJean-michel.saliou@pasteur-lille.fr
lab head
SALIOU Jean-Michel
contact affiliationInstitut Pasteur de Lille
contact emailjean-michel.saliou@pasteur-lille.fr
dataset submitter
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Dataset FTP location
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