PXD020900 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Streamlining of defenses against copper makes host-restricted pathogen reliant on custom-made operon |
Description | Copper is both essential and toxic to living beings, which therefore tightly control its intracellular concentration. At the host-pathogen interface, copper is used by phagocytic cells to kill invading microorganisms. We investigated copper homeostasis in the whooping cough agent Bordetella pertussis, which lives in the human respiratory mucosa and has no environmental reservoir. B. pertussis has considerably streamlined copper homeostasis mechanisms relative to other Gram-negative bacteria. Its single remaining defense line against copper intoxication consists in a metallochaperone diverted for copper passivation and two enzymes involved in peroxide detoxification, which together fight two stresses encountered in phagolysosomes. The three proteins are encoded by an original, composite operon assembled in an environmental ancestor and which is under sensitive control by copper. Interestingly, this system appears to play a role in persistent infection in the nasal cavity of B. pertussis-infected mice. Combining responses to co-occurring stresses in a tailored operon reveals a new strategy adopted by a host-restricted pathogen to optimize survival at minimal energy expenditure. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-09_04:23:52.539.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD020900 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | SALIOU Jean-Michel |
SpeciesList | scientific name: Bordetella bronchiseptica; NCBI TaxID: 518; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-13 22:40:31 | ID requested | |
⏵ 1 | 2021-09-09 04:23:53 | announced | |
Publication List
Rivera-Millot A, Slupek S, Chatagnon J, Roy G, Saliou JM, Billon G, Alaimo V, Hot D, Salom, é, -Desnoulez S, Locht C, Antoine R, Jacob-Dubuisson F, Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon. Commun Biol, 4(1):46(2021) [pubmed] |
Keyword List
submitter keyword: Bordetella pertussis, Copper homeostasis, Phagocytosis, oxidative stress, Evolution, Metallochaperone, host-restricted pathogen |
Contact List
Saliou Jean-Michel |
contact affiliation | Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41 – UMS 2014 – PLBS, F-59000 Lille, France |
contact email | Jean-michel.saliou@pasteur-lille.fr |
lab head | |
SALIOU Jean-Michel |
contact affiliation | Institut Pasteur de Lille |
contact email | jean-michel.saliou@pasteur-lille.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD020900 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020900
- Label: PRIDE project
- Name: Streamlining of defenses against copper makes host-restricted pathogen reliant on custom-made operon