PXD020893

PXD020893 is an original dataset announced via ProteomeXchange.

Title	Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue
Description	The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn major attention. The bioester generated from the Chenopodium quinoa’s oil is a natural-origin ingredient described to produce replenishing skin effects. With this as motivation, we used shotgun proteomics to study the effects of quinoa bioester on human reconstructed epidermis tridimensional cell cultures after 0, 3, 6, 12, 24, and 48 hours of exposure. Our experimental setup employed reversed-phase nano-chromatography coupled online with an Orbitrap-XL and PatternLab for proteomics as the data analysis tool. Extracted ion chromatograms were obtained as surrogates for relative peptide quantitation. Our findings spotlight proteins with increased abundancy, as compared to the untreated cell culture counterparts at same timepoints, that were related to preventing premature aging, homeostasis, tissue regeneration, protection against ultraviolet radiation and oxidative damage.
HostingRepository	PRIDE
AnnounceDate	2020-11-17
AnnouncementXML	Submission_2020-11-16_16:17:46.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amanda Caroline Camillo-Andrade
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-13 01:30:38	ID requested
⏵ 1	2020-11-16 16:17:47	announced

Camillo-Andrade AC, Santos MDM, Fischer JSG, Swinka BB, Bosquetti B, Schuck DC, Pincerati MR, Lorencini M, Carvalho PC, Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue. Sci Rep, 10(1):19392(2020) [pubmed]

submitter keyword: Cosmetics, proteomic, mass spectrometry, reconstructed human epidermis

Paulo Costa Carvalho
contact affiliation	Laboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Curitiba, Paraná, Brazil
contact email	paulo@pcarvalho.com
lab head
Amanda Caroline Camillo-Andrade
contact affiliation	Fiocruz-PR
contact email	amandacamillodea@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD020893

PRIDE project URI

• PRIDE
  1. PXD020893
     1. Label: PRIDE project
     2. Name: Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue