PXD020842

PXD020842 is an original dataset announced via ProteomeXchange.

Title	Proteomics sequencing analysis revealed the pathogenesis of arterial dissection caused by hypertension
Description	Aortic dissection (AD) is a devastating disease with rapid progression and high mortality, and hypertension is a leading cause for AD. The aim of this study was to compare the protein expression profiles of aortas from patients with and without AD, screen vital proteins and explore their potential roles to grasp a further understanding of the pathogenesis mechanism of AD. The results of Tandem Mass Tag (TMT) sequencing revealed the different protein expression profiles between AD and control groups. 131 proteins were significantly upregulated and 239 proteins were prominently downregulated in AD. Upon further enrichment analysis of differential proteins, we found that 5 signaling pathways changed significantly in AD such as glycolysis, ECM and the other three pathways. Moreover, PPI networks were constructed to locate nodal proteins that may be essential points for AD. Our observation demonstrates for the first time that the protein expression in AD was notably changed compared to the control. Our results present evidences that glycolysis and ECM signaling pathway may present a promising approach for the etiology of AD.
HostingRepository	PRIDE
AnnounceDate	2020-09-14
AnnouncementXML	Submission_2020-09-13_22:38:43.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xi Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-11 01:42:45	ID requested
⏵ 1	2020-09-13 22:38:43	announced

Dataset with its publication pending

submitter keyword: Aortic dissection

Proteomics

Signaling pathway

Glycolysis

extracellular matrix

Yu-mei Li
contact affiliation	1 Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, China 2 Department of Toxicology, Fujian Center for Evaluation of New Drug, Fujian Medical University, Fuzhou, China
contact email	liyumei@fjmu.edu.cn
lab head
Xi Yang
contact affiliation	Fujian Medical University
contact email	470546730@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD020842

PRIDE project URI

• PRIDE
  1. PXD020842
     1. Label: PRIDE project
     2. Name: Proteomics sequencing analysis revealed the pathogenesis of arterial dissection caused by hypertension