PXD020794

PXD020794 is an original dataset announced via ProteomeXchange.

Title	Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.
Description	Neuron derived exosomes have been enriched from plasma using L1CAM antigen. Vesicles were enriched from plasma of Parkinson Disease patients and controls. The NDE morphology was observed by transmission electron microscope (TEM). miRNA-155 content was studied both in PD-NDE and control-NDE. LC-MS/MS was applied to verify the reproducibility of the NDE enrichment procedure and to assay PD-NDE protein profiles.
HostingRepository	PRIDE
AnnounceDate	2020-11-26
AnnouncementXML	Submission_2020-11-25_23:53:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Federica Anastasi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-07 04:20:03	ID requested
⏵ 1	2020-11-25 23:53:02	announced

Anastasi F, Greco F, Dilillo M, Vannini E, Cappello V, Baroncelli L, Costa M, Gemmi M, Caleo M, McDonnell LA, Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model. Sci Rep, 10(1):20498(2020) [pubmed]

submitter keyword: neuron derived exosomes, proteomics, Parkinson Disease, plasma, L1CAM

Liam A. McDonnell
contact affiliation	Fondazoine Pisana per la Scienza ONLUS - Via ferruccio Giovannini 13, 56107 San Giuliano Terme (PI) - Italy
contact email	liam@fpscience.it
lab head
Federica Anastasi
contact affiliation	Scuola Normale Superiore
contact email	federica.anastasi@sns.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD020794

PRIDE project URI

• PRIDE
  1. PXD020794
     1. Label: PRIDE project
     2. Name: Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.