PXD020744

PXD020744 is an original dataset announced via ProteomeXchange.

Title	Cell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice
Description	Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effects of IL-6 type cytokines. We therefore generated mouse models for liver cell type-specific analysis of IL-6 signalling.
HostingRepository	PRIDE
AnnounceDate	2021-08-20
AnnouncementXML	Submission_2021-08-20_02:52:27.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-05 09:41:15	ID requested
1	2021-08-20 01:02:23	announced
⏵ 2	2021-08-20 02:52:27	announced	2021-08-20: Updated project metadata.

Schumacher N, Yan K, Gandra, ß M, M, ü, ller M, Krisp C, H, ä, sler R, Carambia A, Nofer JR, Bernardes JP, Khouja M, Thomsen I, Chalupsky K, Bolik J, H, ö, lscher C, Wunderlich T, Herkel J, Rosenstiel P, Schramm C, Schl, ü, ter H, Renn, é T, Mittr, ü, cker HW, Rose-John S, Schmidt-Arras D, Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice. J Hepatol, 74(2):407-418(2021) [pubmed]

10.1016/J.JHEP.2020.09.021;

submitter keyword: innate immunity, acute-phase response,IL-6, gp130

Dirk Schmidt-Arras
contact affiliation	Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany
contact email	darras@biochem.uni-kiel.de
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD020744

PRIDE project URI

• PRIDE
  1. PXD020744
     1. Label: PRIDE project
     2. Name: Cell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice