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PXD020696

PXD020696 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIFITM3 amino acid mutants phosphoproteomics
DescriptionTo investigate the role of IFITM3 in B-ALL, patient derived xenograft cells PDX2 were transduced with either a the constitutively membrane associated IFITM3-Y20E mutant or EV control. Additional mutation of PIP3 binding sites within the conserved internal loop region - K83/K104 or R85/R87/K88 - were introduced to test the predicted function of these sites.
HostingRepositoryPRIDE
AnnounceDate2020-12-18
AnnouncementXMLSubmission_2020-12-17_23:31:18.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMark Robinson
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-08-03 02:40:04ID requested
12020-12-17 23:31:19announced
Publication List
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, M, ΓΌ, schen M, cells. Nature, 588(7838):491-497(2020) [pubmed]
Keyword List
submitter keyword: PDX B-ALL B-cell
Contact List
Markus Muschen
contact affiliationDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, CA, USA
contact emailmmuschen@coh.org
lab head
Mark Robinson
contact affiliationCity of Hope
contact emailmarrobinson@coh.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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