<<< Full experiment listing

PXD020614

PXD020614 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePassage of transmissible cancers in the Tasmanian devil is due to a dominant, shared peptide motif and a limited repertoire of MHC-I allotypes
DescriptionTransmissible cancers are spread via the passage of malignant cells. The survival of the Tasmanian devil, the largest marsupial carnivore, is threatened by two independent transmissible cancers, devil facial tumour (DFT) 1 and devil facial tumour 2 (DFT2). To aid the development of a peptide vaccine and to interrogate how histocompatibility barriers can be overcome, we analysed the peptides bound to Major Histocompatibility Complex class I molecules from the Tasmanian devil and its transmissible tumours.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:51:36.310.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSri Ramarathinam
SpeciesList scientific name: Sarcophilus harrisii; NCBI TaxID: 9305;
ModificationListmonohydroxylated residue; acetylated residue; deamidated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-28 05:10:21ID requested
12021-02-07 23:28:24announced
22023-11-14 08:51:42announced2023-11-14: Updated project metadata.
Publication List
Gastaldello A, Ramarathinam SH, Bailey A, Owen R, Turner S, Kontouli N, Elliott T, Skipp P, Purcell AW, Siddle HV, The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif. Immunology, 163(2):169-184(2021) [pubmed]
Keyword List
submitter keyword: contagious cancer, MHC, marsupial,Transmissible cancer, Tasmanian devil, immunopeptidome
Contact List
Anthony Wayne Purcell
contact affiliationDeputy Head (Research), Department of Biochemistry and Molecular Biology, Head Immunoproteomics Laboratory, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Victoria, Australia
contact emailanthony.purcell@monash.edu
lab head
Sri Ramarathinam
contact affiliationMonash University
contact emailsri.ramarathinam@monash.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD020614
PRIDE project URI
Repository Record List
[ + ]