PXD020530

PXD020530 is an original dataset announced via ProteomeXchange.

Title	Palaeoproteomic analysis of Pleistocene cave hyenas from east Asia
Description	Spotted hyena (Crocuta crocuta) is the only extant species of the genus Crocuta, which once occupied a much wider range during the Pliocene and Pleistocene. However, its origin and evolutionary history is somewhat contentious due to discordances being found between morphological, nuclear, and mitochondrial data. Due to the limited molecular data from east Asian Crocuta, and the difficulty of extracting ancient DNA from this area, here we present proteomic analysis of cave hyenas from three locations in northern China. This marks the first proteomic data generated from cave hyenas, adding new molecular data to the east Asian populations. Phylogenetic analysis based on these protein sequences reveals two different groups of cave hyenas in east Asia, one of which could not be distinguished from modern spotted hyenas from northern Africa, tentatively the result of previously suggested gene flow between these lineages. With developments of instrumentation and analytical methods, proteomics holds promising potential for the phylogenetic reconstruction of ancient fauna previously thought to be unreachable using ancient DNA.
HostingRepository	PRIDE
AnnounceDate	2020-10-19
AnnouncementXML	Submission_2020-10-19_01:13:35.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD020530
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Huiyun Rao
SpeciesList	scientific name: Crocuta; NCBI TaxID: 9677;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-23 04:41:01	ID requested
⏵ 1	2020-10-19 01:13:36	announced

Rao H, Yang Y, Liu J, Westbury MV, Zhang C, Shao Q, Palaeoproteomic analysis of Pleistocene cave hyenas from east Asia. Sci Rep, 10(1):16674(2020) [pubmed]

submitter keyword: Cave hyenas, Palaeoproteomics, Phylogenetic reconstruction, Northern China

Huiyun Rao
contact affiliation	Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences
contact email	raohuiyun@ivpp.ac.cn
lab head
Huiyun Rao
contact affiliation	Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences
contact email	raohuiyun@ivpp.ac.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD020530
     1. Label: PRIDE project
     2. Name: Palaeoproteomic analysis of Pleistocene cave hyenas from east Asia