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PXD020524

PXD020524 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHistone H1 profiling in breast cancer samples
DescriptionEpigenetic aberrations have been recognized as important contributors to cancer onset and development, and increasing evidence suggests that linker histone H1 variants may serve as biomarkers useful for patient stratification, as well as play an important role as drivers in cancer. Although traditionally histone H1 levels have been studied using antibody-based methods and RNA expression, these approaches suffer from limitations. Mass-spectrometry (MS)-based proteomics represents the ideal tool to accurately quantify relative changes in protein abundance within complex samples. We used a label-free quantification approach to simultaneously analyze all somatic histone H1 variants in breast cancer patient samples (different areas laser-microdissected from the same tumor sections, and triple negative samples with/without relapse 3 years after chemotherapy.
HostingRepositoryPRIDE
AnnounceDate2023-05-14
AnnouncementXMLSubmission_2023-05-14_14:04:11.204.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRobertaNoberini
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-23 03:02:56ID requested
12021-03-16 04:56:24announced
22023-05-14 14:04:11announced2023-05-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: EPIC-XS
submitter keyword: breast cancer,histone H1
Contact List
TizianaBonaldi
contact affiliationEuropean Institute of Oncology, Milan
contact emailTiziana.bonaldi@ieo.it
lab head
RobertaNoberini
contact affiliationIstituto Europeo di Oncologia
contact emailroberta.noberini@ieo.it
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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