PXD020410

PXD020410 is an original dataset announced via ProteomeXchange.

Title	Sentinel Lymph Node and Endometrial Cancer Grade in depth Proteomic Analyses : A Novel Approach for Molecular Diagnosis
Description	Endometrial cancer is the most common gynecological cancer worldwide. In women from developed countries, endometrial cancer is usually detected after the age of 60 years. Nearly 90% of the diagnosed cases are sporadic, while 10% are attributed to genetic factors. Thus, it is necessary to develop a diagnostic platform. Currently, the lymph node status is a major prognostic factor in assessing endometrial cancer. However, despite its high sensitivity, it is still in debate. In order to increase its selectivity and specificity, in-depth proteomic study has been performed on patients sentinel lymph node (SNL) samples and on grade I to grade III endometrial carcinoma (EC) samples. We identified specific markers of bad diagnosis that clearly correlate SNL to EC i.e. PRSS3, PTX3, ASS1, YBX2, RBM25, MUC5B. These markers have also been detected in TCGA. By contrast, we also detected good prognosis markers for the overall survival such as CD74, GOLM1, SLC9A3R2, SP100 proteins. Markers for EC and SNL cancer-grading have also been identified. Taken together, it is now possible to propose a novel approach for molecular diagnosis, prognosis and patient’s stratification in EC which will be of excellent utility in therapeutic decision.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:28:52.035.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Soulaimane Aboulouard
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-17 01:08:26	ID requested
1	2021-09-09 07:05:10	announced
⏵ 2	2024-10-22 05:28:52	announced	2024-10-22: Updated project metadata.

Aboulouard S, Wisztorski M, Duhamel M, Saudemont P, Cardon T, Narducci F, Lemaire AS, Kobeissy F, Leblanc E, Fournier I, Salzet M, In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer. Cell Rep Med, 2(6):100318(2021) [pubmed]

10.1016/j.xcrm.2021.100318;

submitter keyword: Ghost proteome, Endometrial Cancer, Proteomic, diagnosis,Sentinel Lymph Nodes, Protein mutations, Small prot

Michel Salzet
contact affiliation	PRISM laboratory Inserm U1192, France, Lille University
contact email	michel.salzet@univ-lille.fr
lab head
Soulaimane Aboulouard
contact affiliation	PRISM
contact email	soulaimane.aboulouard@univ-lille.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD020410

PRIDE project URI

• PRIDE
  1. PXD020410
     1. Label: PRIDE project
     2. Name: Sentinel Lymph Node and Endometrial Cancer Grade in depth Proteomic Analyses : A Novel Approach for Molecular Diagnosis