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PXD020387

PXD020387 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleN-glycosylation analysis of human alpha-1-acid glycoprotein LC-MS
DescriptionAlpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists 45% of carbohydrates attached in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:17:21.331.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarko Tijardović
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
Instrumentcompact
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-15 15:36:33ID requested
12021-01-04 06:18:03announced
22024-10-22 05:17:22announced2024-10-22: Updated project metadata.
Publication List
10.1074/mcp.ra120.002433;
Keyword List
submitter keyword: AGP, LC-MS, high troughput,N-glycosylation
Contact List
Olga Gornik Kljaić
contact affiliationFaculty of Pharmacy and Biochemistry, University of Zagreb
contact emailogornik@pharma.unizg.hr
lab head
Marko Tijardović
contact affiliationFaculty of Pharmacy and Biochemistry, University of Zagreb
contact emailmtijardovic@pharma.hr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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