PXD020387 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | N-glycosylation analysis of human alpha-1-acid glycoprotein LC-MS |
Description | Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists 45% of carbohydrates attached in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:17:21.331.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marko Tijardović |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | compact |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-07-15 15:36:33 | ID requested | |
1 | 2021-01-04 06:18:03 | announced | |
⏵ 2 | 2024-10-22 05:17:22 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: AGP, LC-MS, high troughput,N-glycosylation |
Contact List
Olga Gornik Kljaić |
contact affiliation | Faculty of Pharmacy and Biochemistry, University of Zagreb |
contact email | ogornik@pharma.unizg.hr |
lab head | |
Marko Tijardović |
contact affiliation | Faculty of Pharmacy and Biochemistry, University of Zagreb |
contact email | mtijardovic@pharma.hr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020387
- Label: PRIDE project
- Name: N-glycosylation analysis of human alpha-1-acid glycoprotein LC-MS