PXD020376

PXD020376 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Genome- and proteome-wide analysis of lysine acetylation in Vibrio vulnificus Vv180806 reveals its regulatory roles in virulence and antibiotic resistance
Description	V. vulnificus is an emergent pathogen and causes deadly septicemia in human. Protein acetylation regulates many important biological processes in bacteria. In this study, we identified the first lysine acetylome of V. vulnificus based on the whole-genome sequence of a cefoxitin-resistant strain isolated from a mortality case in China. A total of 6,626 acetylation sites at 1,924 acetylated proteins were uncovered, which to our knowledge represented the largest acetylated protein number that has been identified in bacteria. The presence of acetylation sites in virulence- and antibiotic resistance-related proteins further indicated the important role of acetylated modification on bacterial virulence and antibiotic resistance. Further investigation on the regulatory mechanisms will provide a better understanding of pathogen-host interactions in this increasingly pathogen.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:15:56.089.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Pang
SpeciesList	scientific name: Vibrio vulnificus VV; NCBI TaxID: 1009845;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-15 06:50:36	ID requested
1	2020-12-01 08:33:29	announced
⏵ 2	2024-10-22 05:15:56	announced	2024-10-22: Updated project metadata.

Publication List

10.3389/fmicb.2020.591287;
Pang R, Li Y, Liao K, Guo P, Li Y, Yang X, Zhang S, Lei T, Wang J, Chen M, Wu S, Xue L, Wu Q, Vv180806 Reveals Its Regulatory Roles in Virulence and Antibiotic Resistance. Front Microbiol, 11():591287(2020) [pubmed]

10.3389/fmicb.2020.591287;

Pang R, Li Y, Liao K, Guo P, Li Y, Yang X, Zhang S, Lei T, Wang J, Chen M, Wu S, Xue L, Wu Q, Vv180806 Reveals Its Regulatory Roles in Virulence and Antibiotic Resistance. Front Microbiol, 11():591287(2020) [pubmed]

Keyword List

submitter keyword: Vibrio vulnificus
whole genome sequencing
acetylome
virulence
antibiotic resistance

submitter keyword: Vibrio vulnificus

whole genome sequencing

acetylome

virulence

antibiotic resistance

Contact List

Rui Pang
contact affiliation	Guangdong Institute of Microbiology, Guangdong Academy of Sciences
contact email	pr839@163.com
lab head
Rui Pang
contact affiliation	Guangdong Institute of Microbiology
contact email	pr839@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD020376
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD020376

PRIDE project URI

Repository Record List

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