PXD020370

PXD020370 is an original dataset announced via ProteomeXchange.

Title	SLC15A4 functions as a metabolic guardian of immune cells by controlling mTORC1 and AMPK
Description	Solute carrier family 15 member A4 (SLC15A4) is a lysosome-resident amino acid/oligopeptide transporter preferentially expressed in immune cells, and plays critical roles in the pathogenesis of lupus and colitis in murine model. SLC15A4 is required for TLR7/9- or NOD1-mediated inflammatory responses through mTORC1 regulation or transporting NOD1 ligand, TriDAP, respectively. To further understand the mechanisms of SLC15A4’s action in inflammatory responses, we applied proximity-dependent biotin identification experiment (BioID) to SLC15A4, and identified a panel of proteins including mTORC1 and its regulator that associate with and/or are proximate to SLC15A4 in vivo.
HostingRepository	PRIDE
AnnounceDate	2021-08-11
AnnouncementXML	Submission_2021-08-10_18:23:00.809.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD020370
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Takehiro Suzuki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-14 22:59:50	ID requested
⏵ 1	2021-08-10 18:23:01	announced

Dataset with its publication pending

submitter keyword: SLC15A4 BioID

Naoshi Dohmae
contact affiliation	Biomolecular characterization unit, Center for Sustainable Resource Science, RIKEN
contact email	dohmae@riken.jp
lab head
Takehiro Suzuki
contact affiliation	RIKEN Center for Sustainable Resource Science
contact email	takehirosuzuki@riken.jp
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD020370
     1. Label: PRIDE project
     2. Name: SLC15A4 functions as a metabolic guardian of immune cells by controlling mTORC1 and AMPK