PXD020351
PXD020351 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Both wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development |
Description | Millions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in epidermal development. Finally, functional epidermal 3D organoids with polarity were cultured using wnt3a and the supernatant derived from epidermal stem cells and fresh medium in a 1:1 ratio. These results provide novel directions for the improvement of skin organoids and their potential in clinical application. |
HostingRepository | iProX |
AnnounceDate | 2020-07-14 |
AnnouncementXML | Submission_2022-11-22_00:56:15.667.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jie Ma |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-07-13 23:02:45 | ID requested | |
⏵ 1 | 2022-11-22 00:56:16 | announced |
Publication List
Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z, Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth. Stem Cell Res Ther, 11(1):415(2020) [pubmed] |
Keyword List
submitter keyword: Epidermal stem cell, exosome, organoids, proteomics |
Contact List
Ling Leng | |
---|---|
contact affiliation | Translational Medicine Center, Peking Union Medical College Hospital. |
contact email | zhenlinger@126.com |
lab head | |
Jie Ma | |
contact affiliation | National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics, |
contact email | majie729@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |