PXD020329

PXD020329 is an original dataset announced via ProteomeXchange.

Title	Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
Description	Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.
HostingRepository	PRIDE
AnnounceDate	2020-10-22
AnnouncementXML	Submission_2020-10-21_22:33:37.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marie Vajrychová
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylthiolated residue; monohydroxylated residue; acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-13 01:46:17	ID requested
⏵ 1	2020-10-21 22:33:38	announced

Vajrychov, á M, Str, á, n, í, k J, Pimkov, á K, Barman M, Kukla R, Zedn, í, kov, á P, Bolehovsk, á R, Pl, í, š, kov, á L, Hornychov, á H, Andr, ý, s C, Tambor V, Len, č, o J, Jacobsson B, Kacerovsk, ý M, Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes. Sci Rep, 10(1):17696(2020) [pubmed]

submitter keyword: late PPROM, MIAC, HCA, amniotic fluid proteome, Tandem Mass Tag-based LC-MS/MS

Marie Vajrychova
contact affiliation	Biomedical Research Center, University Hospital Hradec Kralove, Czechia
contact email	marie.vajrychova@fnhk.cz
lab head
Marie Vajrychová
contact affiliation	Biomedical Research Center, University Hospital Hradec Králové
contact email	marie.vajrychova@fnhk.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD020329

PRIDE project URI

• PRIDE
  1. PXD020329
     1. Label: PRIDE project
     2. Name: Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes