PXD020294 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Serum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome |
Description | In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows that 6% of babies exposed to ZIKV during pregnancy have complications present at birth, and this rate rises to 14% when medical monitoring is performed in all exposed babies, regardless of birth condition. Thus, the evaluation and monitoring of all exposed babies are of foremost importance as the development of late complications has been increasingly supported by clinical evidence. The identification of molecular markers in infants exposed to ZIKV without CZS could provide valuable means to improve their clinical monitoring. Here, we used a shotgun-proteomic approach to investigate molecular markers in the serum of infants without CZS symptoms but exposed to ZIKV intrauterine (ZIKV) compared to non-exposed controls (CTRL). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:27:38.390.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Livia Rosa-Fernandes |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos; Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-07-09 22:51:15 | ID requested | |
1 | 2021-09-08 19:26:46 | announced | |
⏵ 2 | 2024-10-22 05:27:46 | announced | 2024-10-22: Updated project metadata. |
Publication List
Macedo-da-Silva J, Rosa-Fernandes L, Barbosa RH, Angeli CB, Carvalho FR, de Oliveira Vianna RA, Carvalho PC, Larsen MR, Cardoso CA, Palmisano G, Exposure to Zika Virus Without Congenital Zika Syndrome. Front Cell Infect Microbiol, 10():577819(2020) [pubmed] |
10.3389/fcimb.2020.577819; |
Keyword List
submitter keyword: ZIKA Virus, CZS,Serum |
Contact List
Giuseppe Palmisano |
contact affiliation | Glycobiology Laboratory |
contact email | palmisano.gp@gmail.com |
lab head | |
Livia Rosa-Fernandes |
contact affiliation | SDU |
contact email | liviarosa.f@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020294
- Label: PRIDE project
- Name: Serum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome