PXD020294

PXD020294 is an original dataset announced via ProteomeXchange.

Title	Serum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome
Description	In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows that 6% of babies exposed to ZIKV during pregnancy have complications present at birth, and this rate rises to 14% when medical monitoring is performed in all exposed babies, regardless of birth condition. Thus, the evaluation and monitoring of all exposed babies are of foremost importance as the development of late complications has been increasingly supported by clinical evidence. The identification of molecular markers in infants exposed to ZIKV without CZS could provide valuable means to improve their clinical monitoring. Here, we used a shotgun-proteomic approach to investigate molecular markers in the serum of infants without CZS symptoms but exposed to ZIKV intrauterine (ZIKV) compared to non-exposed controls (CTRL).
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-08_19:26:46.129.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Livia Rosa-Fernandes
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-09 22:51:15	ID requested
⏵ 1	2021-09-08 19:26:46	announced

Macedo-da-Silva J, Rosa-Fernandes L, Barbosa RH, Angeli CB, Carvalho FR, de Oliveira Vianna RA, Carvalho PC, Larsen MR, Cardoso CA, Palmisano G, Exposure to Zika Virus Without Congenital Zika Syndrome. Front Cell Infect Microbiol, 10():577819(2020) [pubmed]

submitter keyword: Serum, ZIKA Virus, CZS

Giuseppe Palmisano
contact affiliation	Glycobiology Laboratory
contact email	palmisano.gp@gmail.com
lab head
Livia Rosa-Fernandes
contact affiliation	SDU
contact email	liviarosa.f@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD020294

PRIDE project URI

• PRIDE
  1. PXD020294
     1. Label: PRIDE project
     2. Name: Serum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome