PXD020216

PXD020216 is an original dataset announced via ProteomeXchange.

Title	Proteomics of lung tissues from COVID19 patients
Description	Coagulopathy is a hallmark finding in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with an increased risk of death from venous and arterial thromboembolic complications. SARS-CoV-2 infection can lead to microvascular thrombosis that contributes to acute lung injury and respiratory failure. The molecular mechanisms leading to thrombosis in Coronavirus disease 2019 (COVID19) patients are poorly understood. Here, we study a role of the procoagulant neutrophil extracellular traps (NETs)/Factor XII (FXII) axis in COVID19-associated thromboembolism.
HostingRepository	PRIDE
AnnounceDate	2021-08-20
AnnouncementXML	Submission_2021-08-20_00:19:03.371.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD020216
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-06 02:24:43	ID requested
⏵ 1	2021-08-20 00:19:04	announced

Englert H, Rangaswamy C, Deppermann C, Sperhake JP, Krisp C, Schreier D, Gordon E, Konrath S, Haddad M, Pula G, Mailer RK, Schl, ü, ter H, Kluge S, Langer F, P, ü, schel K, Panousis K, Stavrou EX, Maas C, Renn, é T, Frye M, Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine, 67():103382(2021) [pubmed]

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: COVID19, SARS-CoV-2 Infection, Pulmonary Thromboinflammation, Pulmonary Thromboembolism, Pulmonary Thrombosis

Maike Frye
contact affiliation	Institute for Clinical Chemistry and Laboratory Medicine, Vascular Biology Laboratory, University Medical Center Hamburg, Hamburg, Germany
contact email	m.frye@uke.de
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD020216

PRIDE project URI

• PRIDE
  1. PXD020216
     1. Label: PRIDE project
     2. Name: Proteomics of lung tissues from COVID19 patients