PXD020159

PXD020159 is an original dataset announced via ProteomeXchange.

Title	Definition of key mechanisms of multidrug resistance of head and neck tumors to chemo- and radiotherapy treatments. Identification of new individualized antitumor drugs (Ref. GC16173720CARR)
Description	Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide, with an incidence of about 600,000 new cases per year, accounting for 1-2% of all cancer deaths worldwide. Current treatment for head and neck cancer includes taxol (docetaxel), platinum compounds (e.g. cisplatin or carboplatin) and the anti metabolite 5 fluorouracil (5 FU), either as single agents or in combination, and also radiotherapy. Response rates to these chemotherapeutic drugs range from 60 to 80%, however there are high rates of resistance, which often leads to locoregional recurrence and metastasis. The therapeutic dose of treatment needed (hormone therapy, radiotherapy or chemotherapy) is often too toxic for the patient to withstand. Therefore, our main objetive in this proyect is the identification of the molecular and cellular mechanisms involved in the acquisition of resistance to chemotherapy as currently key pieces for the discovery of new drugs that allow the development of effective therapies against HNSCC.
HostingRepository	PRIDE
AnnounceDate	2020-11-13
AnnouncementXML	Submission_2020-11-13_07:32:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yoelsis Garcia-Mayea
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-02 15:31:47	ID requested
⏵ 1	2020-11-13 07:32:03	announced

Garcia-Mayea Y, Mir C, Carballo L, Castellvi J, Temprana-Salvador J, Lorente J, Benavente S, Garc, í, a-Pedrero JM, Allonca E, Rodrigo JP, LLeonart ME, TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance. Cancers (Basel), 12(11):(2020) [pubmed]

submitter keyword: Chemoresistance, HNSCC, cancer stem cells

Matilde Esther LLeonart Pajarin
contact affiliation	Biomedical Research in Cancer Stem Cells Group,Pathology Department, Collserola Building, Lab 205,Vall d'Hebron Research Institute (VHIR, Passeig Vall d'Hebron 119-129,Barcelona 08035, Spain. Tel: +34-93-489-4169 FAX: +34-93-274-6708
contact email	matilde.lleonart@vhir.org
lab head
Yoelsis Garcia-Mayea
contact affiliation	Institut de Recerca Hospital Vall d´Hebron (VIHR)
contact email	yoelsis.garcia@vhir.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD020159

PRIDE project URI

• PRIDE
  1. PXD020159
     1. Label: PRIDE project
     2. Name: Definition of key mechanisms of multidrug resistance of head and neck tumors to chemo- and radiotherapy treatments. Identification of new individualized antitumor drugs (Ref. GC16173720CARR)