PXD020148

PXD020148 is an original dataset announced via ProteomeXchange.

Title	Global changes of transcriptomes between 3-month-old and 1-year-old human right atria
Description	Previous study showed that there are more cell cycle active cardiomyocytes (CMs) in 3-month-old (3M) than1-year-old (1Y) human atria, and extracellular matrix (ECM) from mouse atria benefits neonatal CMs proliferation. We investigate the global changes of transcriptomes between 3M and 1Y human atria and whether ECM from 3M human atria improves myocardium infarct recovery. RNAseq results showed that the major changes between 3M and 1Y human atria were ECM. 3M –ECM increased CM cell cycle activities and rescue mouse heart from injury. We conclude that 3M-ECM hold a therapeutic effect on myocardium infarction.
HostingRepository	iProX
AnnounceDate	2020-07-02
AnnouncementXML	Submission_2020-07-02_01:29:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lincai Ye
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-02 01:24:37	ID requested
⏵ 1	2020-07-02 01:29:42	announced

Dataset with its publication pending

submitter keyword: human, transcriptomes, cardiomyocyte, children, atrium, ECM, myocardium infarction

Jinfen Liu
contact affiliation	Shanghai Children's Medical Center
contact email	liujinfen2002@126.com
lab head
Lincai Ye
contact affiliation	Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine
contact email	ylc717@163.com
dataset submitter

iProX dataset URI