PXD020117

PXD020117 is an original dataset announced via ProteomeXchange.

Title	Identifying fecal host biomarkers for the presence and severity of Clostridioides difficile infection using top-down proteomics
Description	Clostridioides difficile is a major cause of healthcare-associated diarrhea in adult patients. Laboratory diagnosis of C. difficile infection (CDI) is challenging as there is no single test combining high sensitivity and specificity, rapid turnaround time and cost efficiency. They also offer no or little correlation with the clinical outcome. Recently, host-based methods have shown satisfactory performance for the diagnosis of infectious diseases. The aim of this study was to discover CDI-specific host biomarkers that correlate with disease stage and severity.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_13:31:13.766.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Momar Ndao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-29 23:06:35	ID requested
⏵ 1	2021-09-09 13:31:14	announced

Golizeh M, Winter K, Roussel L, Landekic M, Langelier M, Loo VG, Ndao M, Vinh DC, Fecal host biomarkers predicting severity of Clostridioides difficile infection. JCI Insight, 6(1):(2021) [pubmed]

submitter keyword: Clostridioides difficile, Clostridium difficile, biomarker discovery, feces, stool, proteomics, mass spectrometry, human, mouse model, alpha-1-antitrypsin, alpha-2-macroglobulin, matrix metalloproteinase-7, immunoglobulin kappa constant, free immunoglobulin light chain

Momar Ndao
contact affiliation	Department of Medicine, McGill University
contact email	momar.ndao@mcgill.ca
lab head
Momar Ndao
contact affiliation	McGill University
contact email	momar.ndao@mcgill.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD020117

PRIDE project URI

• PRIDE
  1. PXD020117
     1. Label: PRIDE project
     2. Name: Identifying fecal host biomarkers for the presence and severity of Clostridioides difficile infection using top-down proteomics