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PXD020109

PXD020109 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDifferential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer
DescriptionColorectal cancer (CRC) patients suffer from the second highest mortality among all cancer entities. In half of all CRC patients, colorectal cancer liver metastases (CRLM) can be observed. Metastatic colorectal cancer is associated with poor overall survival and limited treatment options. Even after successful surgical resection of the primary tumor, metachronous liver metastases occur in one out of eight cases. The only available curative intended treatment is hepatic resection, but metachronous CRLM frequently recur after approximately one year. In this study, we performed a proteome analysis of three recurrent liver metastases of a single CRC patient by mass spectrometry. Despite surgical resection of the primary CRC and adjuvant chemotherapy plus cetuximab treatment, the patient developed three metachronous CRLM which occurred consecutively after 9, 21 and 31 months. We identified a set of 1,132 proteins expressed in the three metachronous CRLM, of which 481 were differentially regulated, including 81 proteins that were associated with the extracellular matrix (ECM). 56 ECM associated proteins were identified as upregulated in the third metastasis, 26 (46%) of which were previously described as negative prognostic markers in CRC, including tenascin C, nidogen 1, fibulin1 and vinculin. These data may reflect an ascending trend of malignancy from the first to the third metachronous colorectal cancer liver metastasis. Additionally, the results indicate different ECM phenotypes for recurrent metachronous metastasis, associated with different grades of malignancy and highlights the importance of individual analysis of molecular features in different, consecutive metastatic events in a single patient.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:32:06.154.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHannah Voß
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-29 15:50:29ID requested
12022-02-15 13:19:36announced
22024-10-22 05:32:08announced2024-10-22: Updated project metadata.
Publication List
10.1007/s10585-020-10058-8;
Vo, ß H, Wurlitzer M, Smit DJ, Ewald F, Alawi M, Spohn M, Indenbirken D, Omidi M, David K, Juhl H, Simon R, Sauter G, Fischer L, Izbicki JR, Molloy MP, Nashan B, Schl, ü, ter H, J, ü, cker M, Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. Clin Exp Metastasis, 37(6):649-656(2020) [pubmed]
Keyword List
submitter keyword: ECM, prognostic factor, colorectal liver metastasis, CRLM, proteomics,colorectal cancer, ECM signatures, metachronous liver metastasis, CRC, extracellular matrix, LC-MS/MS
Contact List
Prof Dr. Manfred Jücker
contact affiliationUniversity Medical Center Hamburg-Eppendorf, Institute of Biochemistry and Signal Transduction
contact emailjuecker@uke.de
lab head
Hannah Voß
contact affiliationUniversity Medical Center Hamburg Eppendorf, Institute of Clinical Chemistry and Laboratory Medicine, Group of Mass Spectrometric Proteomics
contact emailha.voss@uke.de
dataset submitter
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Dataset FTP location
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