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PXD020087

PXD020087 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease
DescriptionAlzheimer’s disease (AD) is a form of dementia characterized by amyloid-β plaques and Tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. Using mass spectrometry, we performed a combined analysis of the tyrosine, serine, and threonine phosphoproteome, and proteome of post-mortem brain tissue from AD patients and aged matched controls. We used a data-centric approach to identify co-correlated signaling networks associated with cellular and pathological changes. We identified two independent pathology clusters that were associated with Tau and oligodendrocyte pathologies. We observed phosphorylation sites on known Tau-kinases as well as other novel signaling factors that were associated with these clusters. Together, these results build a map of pathology-associated phosphorylation signaling activation events occurring in AD.
HostingRepositoryPRIDE
AnnounceDate2021-05-25
AnnouncementXMLSubmission_2021-05-24_22:13:51.387.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD020087
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterNader Morshed
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive; LTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-29 02:18:41ID requested
12021-05-24 22:13:51announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Phosphoproteomics
Alzheimer's disease
Contact List
Forest Michael White
contact affiliationDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (lab head)
contact emailfwhite@mit.edu
lab head
Nader Morshed
contact affiliationMassachusetts Institute of Technology
contact emailmorshed@mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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