PXD020087 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease |
Description | Alzheimer’s disease (AD) is a form of dementia characterized by amyloid-β plaques and Tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. Using mass spectrometry, we performed a combined analysis of the tyrosine, serine, and threonine phosphoproteome, and proteome of post-mortem brain tissue from AD patients and aged matched controls. We used a data-centric approach to identify co-correlated signaling networks associated with cellular and pathological changes. We identified two independent pathology clusters that were associated with Tau and oligodendrocyte pathologies. We observed phosphorylation sites on known Tau-kinases as well as other novel signaling factors that were associated with these clusters. Together, these results build a map of pathology-associated phosphorylation signaling activation events occurring in AD. |
HostingRepository | PRIDE |
AnnounceDate | 2021-05-25 |
AnnouncementXML | Submission_2021-05-24_22:13:51.387.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD020087 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Nader Morshed |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive; LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-29 02:18:41 | ID requested | |
⏵ 1 | 2021-05-24 22:13:51 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Phosphoproteomics |
Alzheimer's disease |
Contact List
Forest Michael White |
contact affiliation | Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (lab head) |
contact email | fwhite@mit.edu |
lab head | |
Nader Morshed |
contact affiliation | Massachusetts Institute of Technology |
contact email | morshed@mit.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD020087
- Label: PRIDE project
- Name: Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease