PXD020058
PXD020058 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Unraveling Oxidative Stress Resistance: Molecular Properties Govern Proteome Vulnerability |
| Description | Oxidative stress leads to damage of protein molecules, particularly accumulation of protein carbonyls. Deleterious effects of protein carbonylation by reactive oxygen species (ROS) make understanding molecular properties determining ROS-susceptibility essential. The radiation-resistant bacterium Deinococcus radiodurans accumulates less carbonylation than sensitive organisms, making it a key model for deciphering properties governing oxidative stress resistance. We measured protein damage by 6.7 kGy of γ-irradiation in Escherichia coli and D. radiodurans by LC-MS/MS, and analyzed this result both to identify protein carbonyls at residue-resolution and quantifying relative abundance changes following irradiation. |
| HostingRepository | iProX |
| AnnounceDate | 2020-10-22 |
| AnnouncementXML | Submission_2020-10-21_20:12:46.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | RogerLChang |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Deinococcus radiodurans R1; NCBI TaxID: 243230; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-06-27 18:54:10 | ID requested | |
| ⏵ 1 | 2020-10-21 20:12:47 | announced |
Publication List
| Chang RL, Stanley JA, Robinson MC, Sher JW, Li Z, Chan YA, Omdahl AR, Wattiez R, Godzik A, Matallana-Surget S, Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation-induced damage. EMBO J, 39(23):e104523(2020) [pubmed] |
Keyword List
| submitter keyword: Deinococcus radiodurans, Escherichia coli, carbonylation, irradiation, redox proteomics |
Contact List
| Sabine Matallana-Sur | |
|---|---|
| contact affiliation | University of Stirling |
| contact email | sabine.matallanasurget@stir.ac.uk |
| lab head | |
| RogerLChang | |
| contact affiliation | Harvard Medical School |
| contact email | roger.l.chang@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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