PXD020051

PXD020051 is an original dataset announced via ProteomeXchange.

Title	ERR agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
Description	A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction, and inflammation, which collectively contribute to age-related kidney disease. Here we studied the role of the nuclear hormone receptors, the estrogen related receptors (ERRs) in regulation of age-related mitochondrial dysfunction and inflammation. ERRs are decreased in aging human and mouse kidneys and preserved in aging mice with lifelong caloric restriction (CR). Our studies identified ERRs as important modulators of age-related mitochondrial dysfunction and inflammation. ERRα, ERRβ, and ERRγ levels are decreased in the aging kidney. Remarkably, only a 4-week treatment of 21-month-old mice with the pan ERR agonist reversed the age-related increases in albuminuria and podocyte loss, mitochondrial dysfunction and inflammatory cytokines, including the cGAS-STING and STAT3 signaling pathways. A 3-week treatment of 21-month-old mice with a STING inhibitor reversed the increases in inflammatory cytokines and the senescence marker p21 but also unexpectedly reversed the age-related decreases in PGC-1α, ERRα, mitochondrial complexes and Mcad expression.
HostingRepository	PRIDE
AnnounceDate	2023-08-02
AnnouncementXML	Submission_2023-08-02_09:54:13.013.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue AndyQi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-26 14:25:15	ID requested
⏵ 1	2023-08-02 09:54:13	announced

Dataset with its publication pending

submitter keyword: , mitochondrial, Aging,ERR, Kidney

Moshe Levi,MD
contact affiliation	Professor of Biochemistry and Molecular & Cellular Biology, Georgetown University, 3900 Reservoir Road, Washington, DC 20057
contact email	Moshe.Levi@georgetown.edu
lab head
Yue AndyQi
contact affiliation	National Cancer Institute/NIH
contact email	andy.qi@nih.gov
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD020051
     1. Label: PRIDE project
     2. Name: ERR agonism reverses mitochondrial dysfunction and inflammation in the aging kidney