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PXD020002 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleParacrine interactions between epithelial cells promote colon cancer growth
DescriptionTumors are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumor growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, we uncovered a paracrine mechanism by which intestinal cancer cells reactivate fetal and regenerative Yap-associated transcriptional programs in neighboring wildtype epithelial cells, rendering them adapted to thrive in the tumor context. We identified the glycoprotein Thrombospondin-1 (Thbs1) as the essential factor that mediates non-cell autonomous morphological and transcriptional responses. Importantly, Thbs1 is associated with bad prognosis in several human cancers. This study reveals the Thbs1-YAP axis as the mechanistic link mediating paracrine interactions between epithelial cells, promoting tumor formation and progression.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterValentin SABATET
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-24 08:00:42ID requested
12022-05-09 00:19:16announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Intestine, Organoids, Tumoroids, SILAC, conditioned medium
Contact List
Damarys Loew
contact affiliationHead of the Curie Institute Mass Spectrometry Platform
contact emaildamarys.loew@curie.fr
lab head
Valentin SABATET
contact affiliationCurie Institute
contact emailvalentin.sabatet@curie.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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