PXD019962
PXD019962 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis of Liver in Diet-induced Hyperlipidemic Mice under Fructus Rosa roxburghii action |
Description | Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect, but the mechanism is still unclear. Hyperlipidemia (HLP) is material basis for atherosclerosis (AS) formation. Under FRR action, TC, TG, LDL, HDL and ASI in serum were regulated to control level. Differentially expressed proteins in liver were analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice. In total, 4460 proteins were quantified, of which 469 proteins showed dramatic changes between each group. According to molecular functions, 25 differentially co-expressed proteins were divided into five categories: substance metabolism, energy transformation and signal transduction, transcription and translation, immune defense. 15 key proteins involved lipids metabolism, which were identified as Cyp7a1, Cyp3a11, Tm7sf2, COAT2, CSAD, RBP3, Lpin1, Dhrs4, Aldh1b1, GK, Acot 4, TSC22D1, PGFS, EHs, GSTM1. Their altered expression suggested that FRR could maintain the metabolism homeostasis by regulating the metabolism of fatty acids, biosynthesis of BAs and steroids, and production of lipid peroxides (LPOs) in mice. It’s first time potential antiatherosclerotic mechanism of FRR regulating blood lipids was explored from protein level, which is of great significance to explore new drug targets for AS. |
HostingRepository | PRIDE |
AnnounceDate | 2021-01-04 |
AnnouncementXML | Submission_2021-01-04_06:52:48.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pingping Song |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-06-22 21:59:28 | ID requested | |
⏵ 1 | 2021-01-04 06:52:48 | announced |
Publication List
Song P, Shen X, Proteomic analysis of liver in diet-induced Hyperlipidemic mice under Fructus Rosa roxburghii action. J Proteomics, 230():103982(2021) [pubmed] |
Keyword List
submitter keyword: Fructus Rosae Roxburghii |
hyperlipidemia |
atherosclerosis |
TMT proteomic analysis |
Contact List
Pingping Song | |
---|---|
contact affiliation | Guizhou Medical University |
contact email | songqian70@163.com |
lab head | |
Pingping Song | |
contact affiliation | Guizhou Medical University |
contact email | songqian70@163.com |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD019962 |
PRIDE project URI |
Repository Record List
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