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PXD019962

PXD019962 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Analysis of Liver in Diet-induced Hyperlipidemic Mice under Fructus Rosa roxburghii action
DescriptionFructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect, but the mechanism is still unclear. Hyperlipidemia (HLP) is material basis for atherosclerosis (AS) formation. Under FRR action, TC, TG, LDL, HDL and ASI in serum were regulated to control level. Differentially expressed proteins in liver were analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice. In total, 4460 proteins were quantified, of which 469 proteins showed dramatic changes between each group. According to molecular functions, 25 differentially co-expressed proteins were divided into five categories: substance metabolism, energy transformation and signal transduction, transcription and translation, immune defense. 15 key proteins involved lipids metabolism, which were identified as Cyp7a1, Cyp3a11, Tm7sf2, COAT2, CSAD, RBP3, Lpin1, Dhrs4, Aldh1b1, GK, Acot 4, TSC22D1, PGFS, EHs, GSTM1. Their altered expression suggested that FRR could maintain the metabolism homeostasis by regulating the metabolism of fatty acids, biosynthesis of BAs and steroids, and production of lipid peroxides (LPOs) in mice. It’s first time potential antiatherosclerotic mechanism of FRR regulating blood lipids was explored from protein level, which is of great significance to explore new drug targets for AS.
HostingRepositoryPRIDE
AnnounceDate2021-01-04
AnnouncementXMLSubmission_2021-01-04_06:52:48.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPingping Song
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-22 21:59:28ID requested
12021-01-04 06:52:48announced
Publication List
Song P, Shen X, Proteomic analysis of liver in diet-induced Hyperlipidemic mice under Fructus Rosa roxburghii action. J Proteomics, 230():103982(2021) [pubmed]
Keyword List
submitter keyword: Fructus Rosae Roxburghii
hyperlipidemia
atherosclerosis
TMT proteomic analysis
Contact List
Pingping Song
contact affiliationGuizhou Medical University
contact emailsongqian70@163.com
lab head
Pingping Song
contact affiliationGuizhou Medical University
contact emailsongqian70@163.com
dataset submitter
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Dataset FTP location
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