PXD019914

PXD019914 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Glycoproteomic Characterization of Human High-Grade Serous Ovarian Cancer
Description	Inter-tumor heterogeneity is a reflective of the coalescence of a myriad of genomic, transcriptional, translational, and post-translational molecular features. To investigate the contribution of protein glycosylation in tumor heterogeneity in high-grade serous ovarian carcinoma (HGSC), we performed mass-spectrometry (MS)-based glycoproteomic characterization of 119 TCGA HGSC tissues. These HGSC tumor tissues have been previously characterized at the genomic and transcriptomic levels, as well as the proteomic and phosphoproteomic levels, by The Cancer Genomic Atlas (TCGA) consortia and the Clinical Proteomic Tumor Analysis Consortium (CPTAC), respectively. Employing two glycoproteomic strategies, Solid-Phase Extraction of Glycosite-containing peptides (SPEG) for glycosite analysis, and intact glycopeptides for investigation of glycosite-specific glycans (IGPs), we profiled the N-linked glycoproteome in HGSCs, identifying and quantifying glycosites and attached glycan structures.
HostingRepository	MassIVE
AnnounceDate	2020-06-20
AnnouncementXML	Submission_2020-06-20_06:11:12.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jianbo Pan
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	deglycosylated asparagine
Instrument	Q Exactive; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-19 21:40:19	ID requested
⏵ 1	2020-06-20 06:11:12	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Glycoproteomics, Tumor heterogeneity, High-Grade Serous Ovarian Carcinoma (HGSC) , Glycosylation, Mass Spectrometry

submitter keyword: Glycoproteomics, Tumor heterogeneity, High-Grade Serous Ovarian Carcinoma (HGSC) , Glycosylation, Mass Spectrometry

Contact List

Hui Zhang
contact affiliation	Department of Pathology, School of Medicine, Johns Hopkins University
contact email	huizhang@jhu.edu
lab head
Jianbo Pan
contact affiliation	Johns Hopkins University
contact email	panjianbo87@gmail.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085613/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085613/