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PXD019909

PXD019909 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
DescriptionHuman skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combined advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantified 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe here the quantitative distribution of structural proteins, known and novel proteins specific to cellular subsets and those with specialized immunological funtions such as cytokines and chemokines. We anticipate this proteomic atlas of human skin will become an essential community resource for basic and translational research (www.skin.science).
HostingRepositoryPRIDE
AnnounceDate2020-11-18
AnnouncementXMLSubmission_2020-11-18_07:45:34.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFabian Coscia
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-19 08:54:24ID requested
12020-11-18 07:45:35announced
Publication List
Dyring-Andersen B, L, ø, vendorf MB, Coscia F, Santos A, M, ø, ller LBP, Cola, ç, o AR, Niu L, Bzorek M, Doll S, Andersen JL, Clark RA, Skov L, Teunissen MBM, Mann M, Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. Nat Commun, 11(1):5587(2020) [pubmed]
Keyword List
submitter keyword: Proteomics, skin, mass spectrometry, protein expression, stratum corneum, dermis, subcutis, T cell, macrophages, mast cell, endothelial cells, melanocytes, collagen, keratin, interleukins
Contact List
Matthias Mann
contact affiliationDept. Proteomics and Signal Transduction Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried (near Munich) Germany
contact emailmmann@biochem.mpg.de
lab head
Fabian Coscia
contact affiliationUniversity of Copenhagen NNF Center for Protein Research
contact emailfabian.coscia@cpr.ku.dk
dataset submitter
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Dataset FTP location
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