PXD019909

PXD019909 is an original dataset announced via ProteomeXchange.

Title	Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Description	Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combined advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantified 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe here the quantitative distribution of structural proteins, known and novel proteins specific to cellular subsets and those with specialized immunological funtions such as cytokines and chemokines. We anticipate this proteomic atlas of human skin will become an essential community resource for basic and translational research (www.skin.science).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:15:31.145.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabian Coscia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-19 08:54:24	ID requested
1	2020-11-18 07:45:35	announced
⏵ 2	2024-10-22 05:15:39	announced	2024-10-22: Updated project metadata.

10.1038/s41467-020-19383-8;

Dyring-Andersen B, L, ø, vendorf MB, Coscia F, Santos A, M, ø, ller LBP, Cola, ç, o AR, Niu L, Bzorek M, Doll S, Andersen JL, Clark RA, Skov L, Teunissen MBM, Mann M, Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. Nat Commun, 11(1):5587(2020) [pubmed]

submitter keyword: protein expression, T cell, skin, mass spectrometry, endothelial cells, macrophages, stratum corneum, interleukins, collagen, dermis,Proteomics, melanocytes, mast cell, keratin, subcutis

Matthias Mann
contact affiliation	Dept. Proteomics and Signal Transduction Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried (near Munich) Germany
contact email	mmann@biochem.mpg.de
lab head
Fabian Coscia
contact affiliation	Max Delbrueck Center for Molecular Medicine
contact email	fabian.coscia@cpr.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD019909

PRIDE project URI

• PRIDE
  1. PXD019909
     1. Label: PRIDE project
     2. Name: Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin