PXD019827

PXD019827 is an original dataset announced via ProteomeXchange.

Title	Synthetic fluoro peptides in neat solvent and complex proteome background
Description	This dataset was generated to model discovery of uncommon and non-canonical PTM by agnostic analysis. Synthetic DFSAFILVEFCR peptides were obtained in three chemoforms, all with carbamidomethylated C12: 1) with unmodified phenylalanines, 2) with fluoro-F2, and 3) with fluoro-F11. Peptide composition and chemical modifications were confirmed using mass spectrometry. Peptides were analyzed in neat solvent for sequence and modification confirmation, and in the context of AML cell tryptic proteome.
HostingRepository	PRIDE
AnnounceDate	2021-07-23
AnnouncementXML	Submission_2021-07-22_23:18:19.119.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alex Kentsis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monofluorinated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-16 23:33:27	ID requested
1	2021-07-22 11:30:05	announced
⏵ 2	2021-07-22 23:18:19	announced	2021-07-23: Updated project metadata.

10.1021/ACS.JPROTEOME.0C00638;

Cifani P, Li Z, Luo D, Grivainis M, Intlekofer AM, Feny, ö D, Kentsis A, Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics. J Proteome Res, 20(4):1835-1848(2021) [pubmed]

submitter keyword: LC-MSMS fluorination modifications PTM Orbitrap Fusion

Alex Kentsis
contact affiliation	Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
contact email	kentsisresearchgroup@gmail.com
lab head
Alex Kentsis
contact affiliation	Memorial Sloan Kettering Cancer Center
contact email	kentsisresearchgroup@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD019827

PRIDE project URI

• PRIDE
  1. PXD019827
     1. Label: PRIDE project
     2. Name: Synthetic fluoro peptides in neat solvent and complex proteome background