PXD019790

PXD019790 is an original dataset announced via ProteomeXchange.

Title	Hippocampal synaptoproteomic changes of susceptibility and resilience of rats to chronic social isolation
Description	The susceptibility to chronic social isolation (CSIS) is associated with development of major depression (MD). Recent studies relate MD with altered expression of synaptic proteins in specific brain regions, whereby some individuals exposed to the stressors are resistant to the stress. To explore the neurobiological underpinnings and identify candidate biomarkers for MD, a comparative proteomic approach was used to map hippocampal synaptic protein alterations of rats exposed to 6 weeks of CSIS, an animal model of depression. This model generates two stress-response phenotypes, reflecting CSIS-sensitive (depressive-like behaviour) and CSIS-resilience, assessed by sucrose preference test. Our aim was to characterize the synaptoproteome changes representative of potential long-term changes in protein expression underlying susceptibility or resilience to stress.
HostingRepository	PRIDE
AnnounceDate	2020-11-27
AnnouncementXML	Submission_2020-11-27_07:47:37.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Victor Costina
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-15 07:30:50	ID requested
⏵ 1	2020-11-27 07:47:37	announced

Peri, ć I, Costina V, Gass P, Findeisen P, Filipovi, ć D, Hippocampal synaptoproteomic changes of susceptibility and resilience of male rats to chronic social isolation. Brain Res Bull, 166():128-141(2021) [pubmed]

submitter keyword: Rat, Hippocampus, Synaptosomal fraction, Proteomics, LC-MS/MS

Peter Findeisen
contact affiliation	Institute for Clinical Chemistry, Medical Faculty Mannheimof the University of Heidelberg (lab head)
contact email	peter.findeisen@medma.uni-heidelberg.de
lab head
Victor Costina
contact affiliation	Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg
contact email	Victor.Costina@medma.uni-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD019790

PRIDE project URI

• PRIDE
  1. PXD019790
     1. Label: PRIDE project
     2. Name: Hippocampal synaptoproteomic changes of susceptibility and resilience of rats to chronic social isolation