This project contains information about pilot phase experiments on alpha-synuclein (aSyn) carried out within the Joint Research Action 4 of the EU project EPIC-XS. aSyn was cross-linked with different cross-linking chemistries using di(succinimidyl suberate) (DSS-d0/d12), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) chloride and pimelic dihydrazide (PDH-d0/d10) either in its monomeric or fibrillar state.