PXD019750

PXD019750 is an original dataset announced via ProteomeXchange.

Title	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
Description	Mitochondrial metabolism has emerged as a promising target against the mechanisms of tumor growth. Herein, we have screened an FDA-approved library to identify drugs that inhibit mitochondrial respiration. The β1-blocker nebivolol specifically hinders oxidative phosphorylation in cancer cells by concertedly inhibiting Complex I and ATP synthase activities. Complex I inhibition is mediated by interfering the phosphorylation of NDUFS7. Inhibition of the ATP synthase is exerted by the overexpression and binding of the ATPase Inhibitory Factor 1 (IF1) to the enzyme. Remarkably, nebivolol also arrests tumor angiogenesis by arresting endothelial cell proliferation. Altogether, targeting mitochondria and angiogenesis triggers a metabolic and oxidative stress crisis that restricts the growth of colon and breast carcinomas. Nebivolol holds great promise to be repurposed for the treatment of cancer patients.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:07:49.305.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019750
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Cristina Nuevo Tapioles
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-15 02:47:29	ID requested
1	2020-06-27 16:38:47	announced
⏵ 2	2024-10-22 05:07:49	announced	2024-10-22: Updated project metadata.

10.6019/PXD019750;

submitter keyword: Human, RP-LC-MS/MS, cells

José M. Cuezva
contact affiliation	1 Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM);2 Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII; 3 Instituto de Investigación Hospital 12 de Octubre; 4 Instituto Madrileño de Estudios Avanzados (IMDEA) Food Institute, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
contact email	jmcuezva@cbm.csic.es
lab head
Cristina Nuevo Tapioles
contact affiliation	Universidad Autónoma de Madrid
contact email	cnuevo@cbm.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD019750

PRIDE project URI

• PRIDE
  1. PXD019750
     1. Label: PRIDE project
     2. Name: Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth