PXD019729

PXD019729 is an original dataset announced via ProteomeXchange.

Title	Differential protein phosphorylation during stage conversion in Toxoplasma gondii
Description	The intracellular parasite Toxoplasma gondii resides within a membrane bound parasitophorous vacuole and secretes an array of proteins to establish this replicative niche during acute stage of infection. When rapidly dividing tachyzoites convert to chronic stage bradyzoites, many secreted proteins are reported to dynamically redistribute as the cyst forms and secreted kinases are known to play a role in cyst formation. Using quantitative phosphoproteome and proteome analysis comparing tachyzoite and bradyzoite stages, we reveal widespread differential phosphorylation of secreted proteins. These data support a model in which secreted kinases and phosphatases are important to dynamically regulate parasite secreted proteins during stage conversion.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:07:12.526.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Malgorzata Broncel
SpeciesList	scientific name: Toxoplasma gondii ME49; NCBI TaxID: 508771; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-11 17:30:28	ID requested
1	2020-06-12 01:13:13	announced
⏵ 2	2024-10-22 05:07:12	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: stage conversion, bradyzoites, phosphorylation, tachyzoites, Toxoplasma

Moritz Treeck
contact affiliation	Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London NW1 1AT, UK
contact email	moritz.treeck@crick.ac.uk
lab head
Malgorzata Broncel
contact affiliation	The Francis Crick Institute
contact email	malgorzata.broncel@crick.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD019729

PRIDE project URI

• PRIDE
  1. PXD019729
     1. Label: PRIDE project
     2. Name: Differential protein phosphorylation during stage conversion in Toxoplasma gondii