PXD019708

PXD019708 is an original dataset announced via ProteomeXchange.

Title	Definition of aberrant MYB CBP/P300 complex in AML
Description	Dysregulated gene expression is one of the most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of the MYB transcriptional co-activator complex. By rapid and selective peptidomimetic interference with the binding of CBP/P300 to MYB, but not CREB or MLL1, we find that the leukemic functions of MYB are mediated by CBP/P300-mediated co-activation of a distinct set of transcriptional factor complexes that are aberrantly assembled with MYB in AML cells. This therapeutic remodeling is accompanied by dynamic redistribution of CBP/P300 complexes to genes that control cellular differentiation and growth. Thus, aberrantly organized transcription factor complexes control convergent gene expression programs in AML cells. These findings establish a compelling strategy for pharmacologic reprogramming of oncogenic gene expression that supports its targeting for leukemias and other human cancers caused by dysregulated gene control.
HostingRepository	PRIDE
AnnounceDate	2020-12-17
AnnouncementXML	Submission_2020-12-17_01:34:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alex Kentsis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-11 01:27:52	ID requested
⏵ 1	2020-12-17 01:34:14	announced

Dataset with its publication pending

submitter keyword: MYB, CBP/P300, AML, LC-MS, Proteomics, Human

Alex Kentsis
contact affiliation	Molecular Pharmacology Program, Sloan Kettering Institute
contact email	kentsisresearchgroup@gmail.com
lab head
Alex Kentsis
contact affiliation	Memorial Sloan Kettering Cancer Center
contact email	kentsisresearchgroup@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD019708
     1. Label: PRIDE project
     2. Name: Definition of aberrant MYB CBP/P300 complex in AML