PXD019694

PXD019694 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics
Description	We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regulates HDAC1 to support the stemness of cancer stem cells (CSCs). This work revealed a novel underlying mechanism, SOX4-HDAC1 axis, for stemness maintenance of human cancer.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:28:43.468.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Zhou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-10 07:22:05	ID requested
1	2021-09-09 03:33:41	announced
⏵ 2	2024-10-22 05:28:44	announced	2024-10-22: Updated project metadata.

Publication List

10.1186/s13578-021-00539-y;
Liu J, Qiu J, Zhang Z, Zhou L, Li Y, Ding D, Zhang Y, Zou D, Wang D, Zhou Q, Lang T, SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study. Cell Biosci, 11(1):23(2021) [pubmed]

10.1186/s13578-021-00539-y;

Liu J, Qiu J, Zhang Z, Zhou L, Li Y, Ding D, Zhang Y, Zou D, Wang D, Zhou Q, Lang T, SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study. Cell Biosci, 11(1):23(2021) [pubmed]

Keyword List

submitter keyword: SOX4, HDAC1, Cancer stemness,Comparative proteomics

submitter keyword: SOX4, HDAC1, Cancer stemness,Comparative proteomics

Contact List

Lei Zhou
contact affiliation	Singapore Eye Research Institute, Ocular Proteomics Lab
contact email	zhou.lei@seri.com.sg
lab head
Lei Zhou
contact affiliation	Singapore Eye Research Institute
contact email	zhou.lei@seri.com.sg
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD019694
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD019694

PRIDE project URI

Repository Record List

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